The objective of the present study was to taste masking of chlorpheniramine maleate (CPM) by spray drying technique and to prepare a PharmagumTM based chewing gum formulations for the treatment of rhinitis, urticaria and allergic disorder conditions. Sucralose and Aerosil�® 200 were used to mask the taste of CPM and the obtained taste masked product was further used in the development of chewable tablet formulations were investigated. Taste masked product and chewing formulations prepared were investigated by differential scanning calorimetry (DSC) and X-ray powder diffraction (PXRD) studies. The chewable tablets were evaluated for thickness, hardness, weight variation, friability, drug content and in vitro dissolution. The DSC and PXRD studies revealed that the compatibility of drug with excipients. Satisfactory results were obtained when tablets evaluated for weight variation, thickness, hardness and friability. In vitro dissolution demonstrated that CPM loaded with PharmagumTM was capable of providing a constant release of the loaded drug over a period of 60 min. The obtained results from the present experiment indicated that PharmagumTM base based formulations of CPM had a positive outcome based on both qualitative observations and quantitative measurements of different parameters.
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